Nano lipid Particles - A New Generation of Solid Lipid Drug Carriers in Drug Delivery

Development of delivery systems for new drug for its safe and effective delivery it into the body is an integral part of drug research program. This is particularly true due to increased incidence of adverse pharmacokinetic behavior of new drugs developed recently. Alternative delivery systems have been researched extensively not only to modulate their kinetic behavior in the body but also to achieve target drug delivery. Among them lipid based colloidal system have high potentiality for success. To overcome stability problems and to achieve high drug loading capacity in lipid nanoparticles, nano-lipid carriers composed of solid and liquid lipids have gained much importance in recent years due to their resistance to lipid polymorphism and structural imperfection in comparison to solid lipid particles. Selection of appropriate lipid composition and their influence on physico-chemical and bio-distribution characters has given ample scope for designing nano-lipid particulates for target delivery to various organs in various pathological conditions. This review covers various salient information on nano-lipid particulate technology including stability, production along with numerous examples of research reports on the subject.